Special products for clinical trials
Booklet labels
Multi-page labels that maximise information capacity within compact packaging. Ideal for multilingual documentation and multi-country studies, featuring an “open and close” system for quick and secure access to essential data, adaptable to multiple container types.
Tear-off labels
Labels with detachable sections that simplify record-keeping and traceability at clinical sites. The dual tracking code reduces the risk of errors and strengthens trial integrity, making it an excellent solution for double-blind studies.
Peel-off labels
Self-adhesive labels with removable portions, designed to transfer product identifiers to clinical documents or secondary packaging, ensuring continuity and safety in product identification.
Tamper-evident carton: TECOBOX
Patented carton that provides an irreversible, visible indication of tampering. Its single-component cardboard structure, free of glue and adhesives, reduces production defects, simplifies manual packaging, and supports recyclability.
RFID/NFC labels
Smart labels that transform each vial or package into a data point. Beyond identification and tracking, they record patient assignment, timings, and storage conditions, including cold chain integrity, ensuring product quality throughout the supply chain.
Therapy adherence: PluggyMed
Patented smart packaging solution for monitoring and supporting therapy adherence in clinical trials. A smart paper wallet paired with a BLE device and cloud platform, adaptable to any blister to create an intelligent system. Detects pill extraction, sends reminders and alerts, and integrates with IRT, EDC, and DCT systems. Sustainable, reusable, and especially suited for hybrid and decentralised trials.
Folding cartons
Robust, customisable cartons for bottles, vials, blister packs, autoinjectors, and special devices. Designed to maintain safety and integrity even under demanding transport and storage conditions. Can be integrated with track & trace technologies.
Leaflets and booklet
Clear and comprehensive information materials, available in both single-language and multilingual formats, they provide patients and healthcare professionals with accurate instructions that comply with regulations and are customised to the clinical protocol, supporting proper understanding and adherence to the investigational treatment.
We protect the therapies of the future
A clinical trial is far more than a simple stage of development: it is a decisive step towards treatments capable of changing patients’ lives. During this stage, accuracy, traceability and security are not mere requirements, but indispensable guarantees.
With over 80 years of experience behind it, Palladio Group transforms the complex issues of clinical packaging and labelling into safe, compliant and customised solutions. All our processes comply with the highest international standards (cGMP, EU GMP, 21 CFR, EU CTR, ISO) and include 100% electronic checks.
With our broad and diversified product portfolio, we assist our customers in managing clinical trial drugs under all storage conditions – from cryogenic through to ambient temperatures. We work alongside pharmaceutical companies in national and global studies to optimise traceability, supply chain performance and treatment compliance, with an approach that is always patient-oriented and sustainable.
Our clinical study services
Product Development & Co-Design
We develop customised solutions with a validated model and advanced software to support management, administration, documentation, blinding, supply chain and data integration in clinical studies.
Thanks to our Innovation Hub network and access to the latest technologies, we integrate innovative tools to develop smart labels and kits with advanced sensor technology.
We work alongside our partners at every stage, from design to the feasibility study and the production of the final solution.
Randomisation & Variable Data
We manage randomisation lists and variable codes for labels and packaging intended for clinical trials, ensuring correct product distribution in accordance with study design. Data accuracy is verified with advanced OCR/OCV controls, fully compliant with regulatory and safety requirements.
Supply Chain Planning
We organise and manage packaging and labeling materials for your trial, forecasting quantities and delivery times. With our Vendor Managed Inventory (VMI) system, stock is automatically replenished as needed, avoiding shortages or unused materials. Through our advanced B2B system and EDI platform, we ensure an integrated and transparent flow between our organisations, optimising inventory, reducing waste, and guaranteeing operational continuity.
Logistics
We have developed a flexible and adaptive structure to ensure materials are delivered where and when needed, also managing last-minute requests:
Stock in Call-Off
We keep a dedicated stock of semi-finished products in our warehouses, ready to be finalised and shipped as required.
Just in Time (P24)
Production within 24 hours, reducing delivery times with 100% visual inspection. With our Just-in-Time capabilities, we support multi-country and multi-site studies, from open-label to double-blind, and provide a strategic asset for titration studies and adaptive trials with unpredictable enrollment rates.
One Stop Shop
Complete planning of production and supply for a wide range of printed components (folding cartons, leaflets, labels). Unified delivery reduces logistical complexity and optimises warehouse space and reception times.
Traceability & Security
Ensuring the integrity and authenticity of investigational medicinal products is crucial to the success of any clinical study. That is why we develop complete serialisation, tamper-evident, anti-counterfeiting and digital Track & Trace solutions, designed to ensure regulatory compliance, advanced protection and maximum transparency throughout the supply chain.
Serialisation
We assign each pack a unique code, in compliance with European Directive 2011/62/EU and the main international standards. We offer direct-to-packaging or self-adhesive label printing solutions and take care of design, testing and integration with your IT systems.
Tamper-evident
We design folding cartons with dedicated die-cut features and apply tamper-evident seals that make any attempt to open or alter the package before it is dispensed to the clinical study subject immediately evident and detectable.
Anti-counterfeiting
We use both visible technologies (holograms, micro-texts, micro-barcodes, QR codes) and invisible technologies (special inks and nano-engineered materials) to protect investigational medicinal products, and integrate into the packaging physical security levels that are extremely difficult for a counterfeiter to replicate.
Digital Track & Trace
Each pack has a ‘digital twin’ that allows traceability throughout the supply chain. Its identity can be easily verified via smartphone by the staff involved in the study, thus guaranteeing product authenticity and tracking.
Sustainability
In addition to our eco-design approach in the development of folding cartons and labels, we support pharmaceutical companies in analysing and reducing the environmental impact of packaging throughout the clinical supply chain, integrating both environmental and economic sustainability. We provide practical tools to facilitate reporting (Corporate Sustainability Reporting Directive) and contribute to achieving emission targets aligned with the Science Based Target initiative.
Life Cycle Assessment (LCA)
We scientifically assess the environmental footprint of packaging across its entire life cycle, from raw material sourcing to disposal. We offer different levels of analysis, from parametric LCA to detailed LCA, depending on the required granularity.
Materials and Process Optimisation
We propose recyclable and low-impact alternatives, reducing CO₂ emissions, waste, and Total Cost of Ownership.
Beyond the standard: ad hoc solutions
Each clinical trial brings specific challenges. With the support of our R&D department and Innovation Hub, we are able to go beyond standard solutions to co-create packaging, labels and services designed specifically to meet the needs of your programme. Do you have an idea? Together we can find the best solution.
PluggyMed
The success of a study depends largely on participant adherence. However, up to 50% of patients fail to follow their treatment regimen correctly, and this can have important consequences, including reduced treatment efficacy, increased data variability, lower ROI and delays in the time-to-market of new therapies. Every day lost means costs that can range from $600,000 to $8 million, but above all patients waiting longer for innovative treatment solutions.
PluggyMed is the Palladio Group’s smart packaging solution for clinical studies and patient support programmes: an innovation that turns any traditional blister pack into an interactive, connected tool. By leveraging intelligent design and digitisation, PluggyMed helps patients to take their therapy correctly and provides sponsors and CROs with reliable data to accelerate the development of new therapies.
Three components, one solution.
Smart Paper Wallet
Fully recyclable cardboard wallet that can be adapted to any blister type, and customised with logos, formats, and messages. It interacts seamlessly with the smart device to provide real-time tracking and support patient adherence.
Smart Device
Compact, pocket-sized, and easy to use. It detects and timestamps every pill removal, providing immediate reminders, warnings, and feedback. BLE connectivity ensures smooth syncing with a dedicated smartphone companion app.
Cloud Platform
Ensures secure, real-time data management. Fully GDPR- and HIPAA-compliant, it offers customisable dashboards and web interfaces, and APIs for integration with existing trial systems such as EDC, IRT, DCT, and CRM. The platform is scalable for both traditional and hybrid or decentralised clinical trials.
Talk to us
Useful materials to download
Catalogues, reports, documents. A space designed to give you easy and immediate access to technical information, to support you in choosing and managing packaging solutions.